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Veterinary Research Forum، جلد ۱۵، شماره ۱، صفحات ۳۵-۴۱
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عنوان انگلیسی The CB1 cannabinoid receptors involvement in anti-epileptic effect of safranal on penicillin-induced epileptiform activity in rats
چکیده انگلیسی مقاله Neuroprotective effects for natural products are supported by several studies. In this regard, safranal, a constitute of saffron, has the potential to exert beneficial effects in neuro-logical disorders such as Parkinson's disease, epilepsy, stroke, multiple sclerosis and Alzheimer's disease. Here, we investigated the effect of safranal on penicillin-induced epileptiform activity. Also, the effects of intracerebroventricular (ICV) microinjection of AM251 as a CB1-cannabinoid receptors antagonist to clarify the possible mechanism of safranal were evaluated. Epileptiform activity was induced by intra-cortical administration of penicillin (300 IU, 1.50 μL) in urethane-anesthetized rats. Electrocorticographic recordings were used to analyze the frequency and amplitude of spike waves. Intraperitoneal injections of safranal at doses of 1.00 and 4.00 mg kg-1 significantly reduced both the number and amplitude of spike waves. The ICV microinjection of AM251 (0.50 μg 2.00 μL-1) significantly increased the frequency and amplitude of spike waves. In addition, the anti-epileptic effect induced by administration of safranal at a dose of 4.00 mg kg-1 was partially prevented by ICV microinjection of 0.50 μg 2.00 μL-1 of AM251. The results showed anti-epileptiform activities for safranal. Central CB1 cannabinergic receptors might be involved in the anti-epileptiform activity of safranal.
کلیدواژه‌های انگلیسی مقاله AM251, epileptiform activity, Penicillin, Rat, Safranal
نویسندگان مقاله Sina Tamaddonfard |
PhD Candidate, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Amir Erfanparast |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Esmaeal Tamaddonfard |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Farhad Soltanalinejad |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_709149_89080e1585b1321594eceb9bbaf223af.pdf
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