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Acta Medica Iranica، جلد ۵۱، شماره ۱۰، صفحات ۶۸۱-۶۸۶
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عنوان انگلیسی Effect of milrinone on short term outcome of patients with myocardial dysfunction undergoing off-pump coronary artery bypass graft: a randomized clinical trial.
چکیده انگلیسی مقاله Myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. This study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing off- pump coronary artery bypass graft (OPCAB). The present study is designed to evaluate the effect of milrinone on myocardial dysfunction. Eighty patients with low ventricular ejection fraction (< 35%), candidate for elective OPCAB, were enrolled in this study. They were randomly assigned to two groups. One group received milrinone (50 μg/kg) intravenously and another group received a saline as placebo followed by 24 hours infusion of each agent (0.5 μg/kg/min). Short outcome of patients such as hemodynamic parameters and left ventricular ejection fraction were variables evaluated. Serum levels of creatine phosphokinase, the MB isoenzyme of creatine kinase, occurrence of arrhythmias and mean duration of mechanical ventilation were significantly lower in milrinone group (P< 0.05). The mean post operative left ventricular ejection fraction was significantly higher in milrinone group (P=0.031). There were no statistical significant differences between the two groups in terms of intra-aortic balloon pump, inotropic support requirement, myocardial ischemia, myocardial infarction, duration of inotropic support, duration of intensive care unit stay, mortality and morbidity rate. Administration of milrinone in patients undergoing OPCAB with low ventricular ejection fraction is useful and effective.
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نویسندگان مقاله مهدی حدادزاده | mehdi hadadzadeh
department of cardiovascular surgery, afshar hospital, shahid sadoughi university of medical sciences, yazd, iran.


سید حبیب حسینی | seyed habib hosseini
department of anesthesiology, afshar hospital, shahid sadoughi university of medical sciences, yazd, iran.


سید محمد یوسف مصطفوی پور منشادی | seyed mohammad yousof mostafavi pour manshadi
department of medicine, ali ben abitaleb medical college, islamic azad university, yazd, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نفیسه نادری | nafiseh naderi
department of medicine, ali ben abitaleb medical college, islamic azad university, yazd, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمود امامی میبدی | mahmood emami meybodi
department of cardiology, afshar hospital, shahid sadoughi university of medical sciences, yazd, iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4383
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