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Acta Medica Iranica، جلد ۵۱، شماره ۹، صفحات ۵۹۱-۵۹۸
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عنوان انگلیسی The role of milk thistle extract in breast carcinoma cell line (MCF-7) apoptosis with doxorubicin.
چکیده انگلیسی مقاله Breast cancer is the most commonly diagnosed invasive malignancy and first leading cause of cancer-related deaths in Iranian women. Based on silymarin's unique characteristics, its application in chemotherapy combined with doxorubicin can be effective to enhance the efficacy together with a reduced toxicity on normal tissues. The present study focus on evaluate the efficacy of silymarin in combination with doxorubicin, on viability and apoptosis of estrogen-dependent breast carcinoma cell line (MCF-7). After being cultured, MCF-7 cells were divided into 8 groups and treated as follows: 1st group received 75 μg silymarin, groups 2, 3, and 4 were treated with 10, 25, and 50 nM doxorubicin, respectively, and groups 5, 6, and 7 respectively received 10, 25, and 50 nM doxorubicin as well as 75 μg silymarin. Viability percentage and apoptosis of the cells were assessed with Trypan Blue staining after 16, 24, and 48 hours. Silymarin has a synergistic effect on the therapeutic potential of doxorubicin. Use of silymarin in combination with doxorubicin can be more effective on the therapeutic potential of doxorubicin and decreases its dose-limiting side effects.
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نویسندگان مقاله حسین رستگار | hussein rastegar
food and drug research center, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

حمیدرضا احمدی آشتیانی | hamidreza ahmadi ashtiani
department of biochemistry and nutrition, school of medicine, zanjan university of medical sciences, zanjan, iran. and department of clinical biochemistry, school of medicine, tarbiat modares university and institue of medicinal plants, tehran, iran. and department of nutritional hygiene, faculty of veterinary, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

صغری انجرانی | soghra anjarani
reference research center lab, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

سعید بکایی | saeed bokaee
faculty of veterinary medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آرش خاکی | arash khaki
women amp;amp; 039;s reproductive health research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

لیلا جوادی | leila javadi
department of nutrition research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4369
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