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Acta Medica Iranica، جلد ۵۱، شماره ۶، صفحات ۳۷۷-۳۸۵
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عنوان انگلیسی Factors affecting the efficacy of pramipexole in patients with restless legs syndrome.
چکیده انگلیسی مقاله Dopamine agonists, particularly nonergot dopamine agonists such as pramipexole, have become the mainstay of therapy for patients with symptoms of restless legs syndrome (RLS). This study was designed to evaluate the factors affecting the efficacy of pramipexole in patients with RLS. Fifty-nine eligible RLS patients referred to neurology clinic of Rasoul-e-Akram Hospital (Tehran, Iran) were recruited in this study. All of the patients received an oral dose of 0.18 mg pramipexole. The severity of RLS symptoms were evaluated including sleep disorder, symptomatic days per week and symptomatic hours per day, both at the beginning and at the end of follow-up time. Different baseline and follow-up variables were also recorded and their relationships with the outcomes were assessed. The mean severity values of different symptoms significantly decreased after treatment with pramipexole (P 50% reduction in symptomatic days per week and symptomatic hours per day. Moreover, the cutoff point of 3.5 mo for duration of treatment could potentially differentiate >50% reduction in severity of sleep disorder from the ones with < 50% reduction with sensitivity and specificity of 56.8% and 78.6%, respectively. Our findings show that female gender and duration of treatment were the factors affecting the effectiveness of pramipexole in RLS patients. If tolerated by the patients, a longer duration of treatment with pramipexole is more effective in RLS.
کلیدواژه‌های انگلیسی مقاله Efficacy,Pramipexole,Restless legs syndrome (RLS),Treatment
نویسندگان مقاله محمد رضوانی | mohammad rezvani
department of neurology, rasool-e akram hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

بابک زمانی | babak zamani
department of neurology, rasool-e akram hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید محمد فرشته نژاد | seyed mohammad fereshtehnejad
division of clinical geriatrics, department of neurobiology, care sciences and society nvs , karolinska institutet, stockholm, sweden. and firoozgar clinical research development center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4427
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زبان مقاله منتشر شده en
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