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Acta Medica Iranica، جلد ۵۱، شماره ۶، صفحات ۴۰۸-۴۱۰
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عنوان انگلیسی Pemphigoid gestationis: a retrospective study in southwest Iran.
چکیده انگلیسی مقاله Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis of pregnancy usually presents in the second or third trimester. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. Pathogenesis of PG is not fully established, however, most patients develop circulating autoantibodies targeting the bullous pemphigoid (BP) 180 antigen. The aim of this work is to draw a profile of the epidemiology, clinical aspects, treatment and evolution of the disease by studying hospital series. We retrospectively investigated the 13 patients who were diagnosed with PG based on hospital data at the Referral Center of Southwest Iran located in Ahvaz city between March 2002 and March 2011. The age of onset was 21 to 40 years (mean age: 27.5 years). The onset of the disease occurred in the second trimester of pregnancy in 6 patients and in the third trimester of pregnancy in 4 patients. One patient had a flare up of disease during the first trimester and two out of cases in puerperium period. In all cases, pruritus was the first symptom, followed by an erythematous vesiculobullous eruption. The diagnosis of PG was confirmed by skin biopsy. Ten out of the patients treated with oral corticosteroids (0.5-1 mg/kg/day), one of the patients underwent oral corticosteroids plus topical glucocorticoid and the last patient treated with topical glucocorticoid. PG remains a rare dermatosis of pregnancy. Our series had two particularities compared to other studies: high frequency in primigravida and the frequent involvement of the face. Additionally our study demonstrated that improvement could occur faster and provide acceptable management if the treatment of the patients would be implemented sooner.
کلیدواژه‌های انگلیسی مقاله Autoimmune,Bullous dermatosis,Pemphigoid gestationis
نویسندگان مقاله سیما رسایی | sima rassai
department of dermatology, jundishapur university of medical sciences, ahvaz, iran.


نادر pazyar | nader pazyar
department of dermatology, jundishapur university of medical sciences, ahvaz, iran.


سید میلاد علوی | seyed milad alavi
department of dermatology, jundishapur university of medical sciences, ahvaz, iran.


افشین کازرونی | afshin kazerouni
department of dermatology, jundishapur university of medical sciences, ahvaz, iran.


امیر فیلی | amir feily
skin and stem cell research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4422
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