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Acta Medica Iranica، جلد ۵۰، شماره ۱۲، صفحات ۸۲۷-۸۳۰
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عنوان انگلیسی A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)
چکیده انگلیسی مقاله Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies.
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نویسندگان مقاله پراسانا kumari | prasanna kumari
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.


بیدادی lingappakavitha | bidadi lingappakavitha
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.


chintaparthi obula reddy | chintaparthi obula reddy
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.


maiana mangalagowri | maiana mangalagowri
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.


danem satienariana madhumathi | danem satienariana madhumathi
department of pathology, hematology unit, kidwai memorial institute of oncology, bangalore, india.


madaiah mahadeva prasad | madaiah mahadeva prasad
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.


hanumanthappa پ سینگ raghavendra | hanumanthappa vijay raghavendra
department of pathology, hematology unit, kidwai memorial institute of oncology, bangalore, india.


chennagiri shinivasa murthy premalata | chennagiri shinivasa murthy premalata
department of pathology, kidwai memorial institute of oncology, bangalore, india.


kuntejowdahalli channaviriappa lakshmaiah | kuntejowdahalli channaviriappa lakshmaiah
department of medical oncology, kidwai memorial institute of oncology, bangalore, 560029, india.


سید هاشم میر مظلومی | seyed hashem mir mazloumi
department of pathology, cytogenetic unit, kidwai memorial institute of oncology, bangalore, india.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4002
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