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Acta Medica Iranica، جلد ۵۰، شماره ۹، صفحات ۵۸۹-۵۹۶
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عنوان انگلیسی Effect of Aqueous Extract of Elaeagnus angustifolia Fruit on Experimental Cutaneous Wound Healing in Rats
چکیده انگلیسی مقاله The present study was conducted to investigate the histological changes and wound healing effect of aqueous extract of Elaeagnus angustifolia. After creating full-thickness skin wounds on the back of 45 male Sprague-Dawley rats they were randomly divided into three groups. Treated group received the extract, positive control group were treated with mupirocin ointment 2% and control group did not receive any treatment. Wound healing rates were calculated on days 3, 5, 8, 10, 12 and 15 post-wounding and the wound tissues were harvested at 5, 10, and 15 days for histological analysis and hydroxyproline content measurement. The results indicated a significant increase in the percentage of wound contraction and hydroxyproline content in the treated group comparing to the control and positive control groups. A significant increase in the assigned histological scores was observed at 10 and 15 days in the treated and positive control groups compared to the control group. The results demonstrate that aqueous extract of Elaeagnus angustifolia accelerates cutaneous wound healing, and its effect may be due to the increased re-epithelialization and collagen deposition in wound and so it can be considered as a therapeutic agent for wound healing.
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نویسندگان مقاله محبوبه مهربانی نطنزی | mahboobeh mehrabani natanzi
department of biochemistry, school of medicine, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

پروین پاسالار | parvin pasalar
department of biochemistry, school of medicine, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

محمد کمالی نژاد | mohammad kamalinejad
depertment of pharmacognosy, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

احمد رضا دهپور | ahmad reza dehpour
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید محمد توانگر | seyed mohammad tavangar
department of pathology, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رویا شریفی | roya sharifi
department of biochemistry, school of medicine, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نغمه قنادیان | naghmeh ghanadian
department of biochemistry, school of medicine, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مریم رحیمی بالایی | maryam rahimi balaei
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سیاوش گرایش نژاد | siavash gerayesh nejad
department of biochemistry, school of medicine, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3956
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