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International Journal of Radiation Research، جلد ۲۲، شماره ۱، صفحات ۱-۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی CO-2 laser surgery for laryngeal cancer: A meta-analysis and systematic review
چکیده انگلیسی مقاله
Background: To evaluate the effectiveness and safety of CO2 laser surgery (CO2-LS) in treating patients with laryngeal cancer (LC) by comparing it with other therapeutic modalities. Materials and Methods: The randomized controlled trials of CO2-LS for LC from the creating day of databases to February 2023 were searched on PubMed, Embase, Web of science databases and the Cochrane library, without language restrictions. Data were extracted independently by two investigators, followed by the article quality assessment and cross-check. This meta-analysis involved five studies with good quality, covering 405 LC patients. Results: Data analysis demonstrated a higher voice handicap index (VHI) in CO2-LS-treated patients compared to the control group at 6 months postoperatively [Odds Ratio (OR) = 1.12, 95% confidence intervals (CI) (0.19, 2.04), P = 0.02], but a lower shimmer value at 3 months postoperatively [OR = 1.04, 95% CI (0.92, 1.17), P<0.00001]. The control group exhibited a lower postoperative mucosal stability compared to the CO2-LS group [OR = 0.41, 95%CI (0.21, 0.79), P=0.008]. The subgroup analysis showed more operation time [OR = 3.48, 95% CI (2.86, 4.10), P<0.00001] compared to the CO2-LS group, with statistically significant difference. Conclusions: Comparing to other treatment modalities, CO2-LS is advantageous in mucosal recovery in LC patients, but not in postoperative survival and vocal quality.
کلیدواژه‌های انگلیسی مقاله Carbon dioxide laser surgery, laryngeal cancer, effectiveness, safety, meta-analysis.
نویسندگان مقاله | S. Zheng
Department of Otorhinolaryngology, General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, FuShun City, Liaoning Province, China


| Y. Zhan
Department of Otorhinolaryngology, Air Force Hospital of the Northern Theatre of the People&apos;s Liberation Army, ShenYang City, Liaoning Province, China


| F. Bao
Department of Pharmacy, Fushun Hospital of Traditional Chinese Medicine, FuShun City, Liaoning Province, China


| T. Gong
Department of Second Interventional Medicine, Shengjing Hospital Affiliated to China Medical University, ShenYang City, Liaoning Province, China


| T. Gong
Department of Second Interventional Medicine, Shengjing Hospital Affiliated to China Medical University, ShenYang City, Liaoning Province, China
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مقاله مروری
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