این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۳، شماره ۲، صفحات ۳۷۶-۳۸۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Proteomics Clustering Research of ITRAQ Markers in Plasma of AIDS Patients with Different Chinese Medicine Syndromes
چکیده انگلیسی مقاله Background: We aimed to distinguish the different Chinese medicine (CM) syndromes of acquired immune deficiency syndrome (AIDS) patients at the proteomics level. Methods: We collected AIDS patients diagnosed with different CM syndromes from Weishi County, Kaifeng City, Henan Province, China, including Qi-deficiency syndrome (named QD group) and dampness-heat syndrome (named DH group). Healthy people were collected as controls from Weishi County, Kaifeng city, Henan Province, China. The plasma from three groups were labeled with ITRAQ, LC/MC was used for protein quantitative analysis. Finally, sequence search and cluster analysis were performed. Results: Overall, 27 different proteins were found. Three proteins were up-regulated and 2 proteins down-regulated in the QD group, 11 proteins up-regulated and 13 proteins down-regulated in the DH group. Compared with DH group, there were 7 different proteins in QD group, among which 5 proteins were down-regulated and 2 proteins were up-regulated. When the target protein of DH group was up-regulated, the protein of HC group was down-regulated correspondingly. Conclusion: The significance analysis and clustering of protein results showed that DH group was significantly different from QD group and HC group at the protein level (P<0.05). However, the QD group could not be effectively distinguished from the HC group. AAT, PF4, C-reactive protein and c4bp may be used as potential biomarkers in DH group. Mass spectrometry based on feature selection can be used to classify different CM syndromes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Haiyan Zhang
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Quan Qiu
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Qingya Li
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Long Feng
Department of Pathogenic Organism Biology, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Dongyang Li
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Miao Zhang
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Juan Wang
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Suna Ma
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China


| Liran Xu
Zhongjing Institute of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou city, Henan Province, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/32542
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات