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Iranian Journal of Public Health، جلد ۵۳، شماره ۲، صفحات ۳۱۳-۳۲۲
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عنوان انگلیسی Efficacy and Safety of Insulin Degludec/Insulin Aspart versus Biphasic Insulin Aspart 30 in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
چکیده انگلیسی مقاله Background: We systematically reviewed and analyzed the efficacy and safety of insulin degludec/insulin aspart (IDegAsp) versus biphasic insulin aspart 30 (BIAsp 30) in patients with type 2 diabetes (T2D). Methods: We used computers to search the Embase, PubMed, Clinical Trials, and the Cochrane Library database, and collected randomized controlled trials (RCTs) on the treatment of IDegAsp versus BIAsp 30 in T2D patients. The research period was from the establishment of the database to May 19, 2023. We used Review Manager 5.20 statistical software for systematic meta-analysis. Results: We included 8 RCTs with 2281 participants. IDegAsp was better to BIAsp30 in improving fasting plasma glucose (FPG) levels (P<0.001) and reducing the endpoint daily average insulin dose (P<0.01). Furthermore, compared with BIAsp30, IDegAsp significantly reduced the risk of nocturnal hypoglycemic events (P<0.001). However, there was no significant difference in the improvement of body weight change (P=0.99), glycosylated hemoglobin (P=0.50), the overall risk of hypoglycemic events (P=0.57) and adverse events (P=0.89) between the two groups. Conclusion: Compared with BIAsp30, IDegAsp could significantly reduce FPG levels, insulin dosage, and the risk of nocturnal hypoglycemic events in T2D patients, without increasing the overall risk of adverse events.
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نویسندگان مقاله | Yan-Li Niu
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Ye Zhang
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Zhi-Yong Song
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Chuan-Zhi Zhao
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Yun Luo
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Yan Wang
Endocrinology Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China


| Jing Yuan
Emergency Department, Luodian Hospital, Baoshan District of Shanghai, Shanghai, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/32189
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