| چکیده انگلیسی مقاله |
Background: One of the most important factors that increases breast cancer (BC) recurrence after Breast-conserving surgery (BCS) is the positivity of the margins, which is found in permanent histological exams. Intra-operative specimen mammography (SM) can reduce the rate of margin positivity and re-operation. Our aim was to examine whether vacuum SM (VSM) is more accurate than standard SM (SSM) in detecting the positivity of the margins. Methods: For this cross-sectional study, in the operating room, excised specimens of 55 women with breast cancer who underwent lumpectomy were oriented by metallic staples and sutures for radiologic and histological assessment, respectively. In the radiology ward, SSM was first taken; then, the specimen was vacuum packed and VSM was performed. Afterwards, the specimen was sent for histopathological analysis as a gold standard for the assessment of surgical margins. Specimens’ margins were classified according to the size of clear margins in millimeters as zero or >0; and ≤1 or >1. Results: The mean age of all participants was 51.22 ± 10.58 years. Totally, 220 margins were assessed. According to classified margins (zero and 1 mm), for the detection of affected margins, the accuracy values of the VSM method were 90.52%, and 87.20% while these figures were 91.51% and 88.68% for SSM. There was substantial agreement between the two methods of detecting the affected margins (VSM and SSM), with Cohen's κ =0.66, 95% CI: 0.34-0.97, P-value <0.001). Finally, there was not a statistically significant difference in the proportion of detecting margin between SSM and VSM (McNemar test P-value =0.63). Conclusion: Specimen mammography with an adequate orientation of the tissue is an accurate and practical method for immediate intraoperative examination of the margin status in BCS, and VSM is not superior to SSM in the detection of affected margins. |
| نویسندگان مقاله |
| Bita Eslami
Breast Diseases Research center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Ramesh Omranipour
1- Breast Diseases Research center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Leila Bayani
Department of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Akram Seifollahi
Department of Pathology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Azin Saberi
Department of Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Behnaz Jahanbin
Department of Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Fahimeh Zeinalkhani
Department of Radiology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Arvin Arian
Department of Radiology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Reyhaneh Sefidabi
Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Marzieh Orouji
Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Zohreh Firoozsamadi
Department of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Hengame Khosravi
Department of Radiology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Soheila Koopaee
Department of Radiology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Mahsa Tavakol
Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Sadaf Alipour
Breast Disease Research Center, TUMS
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