این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Archives of Breast Cancer، جلد ۱۱، شماره ۱، صفحات ۶۷-۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Risk Factors of Response to Neoadjuvant Chemotherapy in Patients with Luminal (HER2 Negative) Breast Cancer: Roc Curve and Logistic Regression Model Results: RF of response to NAC in HER2- BC
چکیده انگلیسی مقاله Background: Neoadjuvant chemotherapy (NAC) is less effective for luminal human epidermal growth factor receptor 2 (HER2) negative breast cancer (BC) patients and generally shows a low pathological complete response (pCR) after NAC compared to HER2 positive and triple negative breast cancer (TNBC). This study aimed to determine the factors associated with histopathologic response following NAC in luminal (HER2 negative) BC. Methods: This is a cross-sectional study conducted on 255 estrogen (ER) positive and HER2 negative BC patients after NAC between January 2018 and July 2023. Demographic and clinicopathological characteristics of the patients were collected for the statistical analysis. Chi-Square tests were used in the qualitative comparisons between study groups. Receiver Operating Characteristic (ROC) analysis was used for the diagnostic performance of Ki-67 expression and ER in determining the pCR rates. Using the Youden index, optimum cut points were determined. Also, multivariate logistic regression analysis was applied to determine the independent variables associated with the dependent variable (pCR). Results: After NAC, pCR was achieved in the breast in 35 (14%) patients, in the axilla in 44 (17%) patients, and in both the breast and axilla in 18 (7%) patients. Ki-67 expression was the only common variable associated with the breast, axilla and both the breast and axilla pCR. The most appropriate Ki-67 expression cut-off value for determining the breast and axilla complete response was found to be 40%. ER positivity level was only associated with pCR in the breast and the cut-off value was found to be 85%. Conclusion: The results of this study raise the possibility of patients with luminal (HER2 negative) BC with Ki-67 expression higher than 40% benefiting from chemotherapy, as they showed increased pCR rates.
کلیدواژه‌های انگلیسی مقاله Breast cancer, Neoadjuvant therapy, estrogen receptor, HER2 negative, pathologic complete response, Ki-67
نویسندگان مقاله | Atilla Bozdogan
Department of Statistics, Institute of Science, Istanbul Ticaret University, Istanbul, Turkey


| Selman Emiroglu
Breast Surgery Division, Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey


| Asmaa Abuaisha
Genetics Department, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey";}


| Ozlem Deniz Basar
Department of Statistics, Institute of Science, Istanbul Ticaret University, Istanbul, Turkey
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/841
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.32768/abc.202411167-74
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات