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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۴، صفحات ۴۱۸-۴۲۴
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عنوان انگلیسی All-trans retinoic acid and fibroblast growth factor-2 enhance the fertility rate and embryo development in polycystic ovary syndrome mouse model
چکیده انگلیسی مقاله Objective(s): Polycystic ovary syndrome (PCOS) causes a developmental arrest of antral follicles and disrupts oocyte maturation. Retinoic acid (RA) and Fibroblast Growth Factor-2 (FGF2) are effective in follicle growth, thus their effects on histopathology and in vitro fertility of oocytes were investigated in PCOS-induced mice.Materials and Methods: Eighty female NMRI mice were randomly divided into 8 groups including 1-Normal mice, 2-PCOS mice without any treatment, 3-Normal mice treated with RA, 4-Normal mice treated with FGF2, 5-PCOS mice treated with RA, 6- PCOS mice treated with FGF2, 7- PCOS mice treated with RA and FGF2, and 8- Normal mice treated with RA and FGF2. Following PCOS induction, the mice were treated with intraperitoneal RA and FGF2 as a treatment. Then ovarian stimulation, for preparing the oocyte and embryo microscopic examinations was performed. After oocyte morphometry, through in vitro fertilization, the embryo formation was assessed. Data was analyzed by one-way ANOVA and Tukey tests.Results: The results showed simultaneous injection of RA and FGF2 into PCOS-induced mice increases antral follicles and corpus luteum, but decreases cystic follicles. Simultaneous injection of these two substances into healthy mice increases the pre-antral follicles and corpus luteum. Simultaneous injection of RA and FGF2 increases the number of embryos in both control and intervention groups. Conclusion: It can be concluded that RA and FGF2 increase the maturity of ovarian follicles, the number of two-celled embryos, and the number of grade-A embryos in mice with PCOS, which is more effective when these two substances are injected simultaneously.
کلیدواژه‌های انگلیسی مقاله Embryo development, Fertility agents, Growth Factor, In vitro oocyte maturation - techniques, Reproduction
نویسندگان مقاله | Auob Rustamzadeh
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Research Institute for Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran


| Maryam Anjomshoa
Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Narjes Bahreini
Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Shahram Darabi
Cellular and Molecular Research Center, Research Institute for Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran


| Mohammad Jafar Rezaei
Cellular and Molecular Research Center, Research Institute for Health Development, Department of Anatomical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Shohreh Rezaei
Cellular and Molecular Research Center, Research Institute for Health Development, Department of Anatomical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Mohammad Rahimi-Madiseh
Medical Plants Research Center, Basic Health Sciences Institute, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Fatemeh Deris
Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Saeed Zamani
Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23649.html
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