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Acta Medica Iranica، جلد ۵۰، شماره ۴، صفحات ۲۲۶-۲۳۲
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عنوان انگلیسی The Effects of Cyclosporin-A on Functional Outcome and Axonal Regrowth Following Spinal Cord Injury in Adult Rats
چکیده انگلیسی مقاله It has been shown that the immunophilin ligands have the special advantage in spinal cord repair. In this study, the effects of cyclosporine A (CsA) on functional recovery and histological outcome were evaluated following spinal cord injury in rats. After spinal cord hemisection in thirty six adult female Sprague-Dawley rats (200- 250 g), treatment groups received CsA (2.5 mg/kg i.p.) at 15min and 24h after lesion (CsA 15min group and CsA 24h group) daily, for 8 weeks. Control and sham groups received normal saline and in sham operated animals the spinal cord was exposed in the same manner as treatment groups, but was not hemisected. Hindlimb motor function was assessed in 1, 3, 5 and 7 weeks after lesion, using locomotive rating scale developed by Basso, Bresnahan and Beattie (BBB). Motor neurons were counted within the lamina IX of ventral horn and lesion size was measured in 5 mm of spinal lumbar segment with the epicenter of the lesion site. The mean number of motor neurons and the mean BBB scale in 3, 5 and 7 weeks in CsA 15min groups significantly increased compared to the control group. Although, the lesion size reduced in rats with CsA treatment compared to the control group, no significant difference was observed. Thus, it can be concluded that CsA can improve locomotor function and histological outcome in the partial spinal cord injury.
کلیدواژه‌های انگلیسی مقاله Cyclosporin A,Recovery of function,Motor neurons,Spinal cord
نویسندگان مقاله امراله روزبهی | amrollah roozbehi
cellular and molecular research center, faculty of medicine, yasuj university of medical sciences, yasouj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

محمد تقی جغتایی | mohammad taghi joghataie
department of anatomy, cellular and molecular research center, faculty of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی مهدی زاده | mehdi mehdizadeh
department of anatomy, cellular and molecular research center, faculty of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی میرزایی | ali mirzaei
department of biochemistry, cellular and molecular research center, faculty of medicine, yasuj university of medical sciences, yasouj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

حمداله دلاویز | hamdollah delaviz
cellular and molecular research center, faculty of medicine, yasuj university of medical sciences, yasouj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3889
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