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Acta Medica Iranica، جلد ۵۰، شماره ۲، صفحات ۹۷-۱۰۰
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عنوان انگلیسی Interferon-beta in Pediatric Multiple Sclerosis Patients: Safety in Short-Term Prescription
چکیده انگلیسی مقاله None of the approved immunomodulatory drugs in adults Multiple Sclerosis (MS) patients have been officially approved for the pediatric patients and are currently used off-label in this population. In this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (Avonex®) and subcutaneously injected interferon beta1-b (Betaferon®) in children with definite relapsing-remitting MS (RRMS). Thirteen patients aged younger than 16, who were recently diagnosed with definite RRMS according to the McDonald's criteria, were enrolled in this study. Six patients were treated with Avonex® 30 μg, intramuscularly every week, and seven patients were treated with Betaferon® 250 μg, subcutaneously every other day. All patients were treated with adult doses; initially interferon-beta was prescribed with half dose, and it was increased to full adult dose steadily. Eleven girls and two boys, mean (SD) age of 14.7 (1.9) years, were studied. Following nine months of using interferon-beta, nine patients (69.2%) had no relapses and the remaining four, experienced only one relapse. The mean EDSS score was decreased significantly after the study period. The present study provides reasonable data for the use of interferon-beta in Pediatric MS due to lack of short-term complications and safety. Studies with larger sample size and longer follow up duration are required to shed light on the long term impact of the interferon-beta therapy in children.
کلیدواژه‌های انگلیسی مقاله Multiple Sclerosis,Pediatrics,Childhood,Interferons
نویسندگان مقاله کیوان بصیری | keivan basiri
neuroscience research center, isfahan university of medical sciences, isfahan, iran. and department of neurology, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مسعود اعتمادی فر | masood etemadifar
neuroscience research center, isfahan university of medical sciences, isfahan, iran. and department of neurology, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فاطمه درخشان | fatemeh derakhshan
neuroscience research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرشته اشتری | fereshteh ashtari
neuroscience research center, isfahan university of medical sciences, isfahan, iran. and department of neurology, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

وحید شایگان نژاد | vahid shaygannejad
neuroscience research center, isfahan university of medical sciences, isfahan, iran. and department of neurology, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زهرا فاتحی | zahra fatehi
neuroscience research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

امیر هادی مغزی | amir hadi maghzi
neuroscience research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرزاد فاتحی | farzad fatehi
department of neurology, shariati hospital, tehran university of medical sciences, tehran, iran. and iranian center of neurological research, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3865
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