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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۱، صفحات ۴۲-۵۲
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عنوان انگلیسی Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer
چکیده انگلیسی مقاله Background and purpose: The insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) have been exhibited to have tumor suppressor effects. Despite their prognostic value in some cancers, they have not been elucidated in gastric cancer. Experimental approach: We collected 68 samples from patients with gastric cancer. IGFBP-3 and IGFBP-3R expression levels were evaluated with quantitative real-time polymerase chain reaction (RT-PCR) and western blotting in patients. The relationship between prognostic factors and IGFBP-3/IGFBP-3R expression was also evaluated. Findings/Results: Our results showed that IGFBP-3 and IGFBP-3R expression was reduced significantly in tumor tissues. We found that there was an association between the reduction of IGFBP-3 with lymph node metastasis and tumor-node-metastasis (TNM) staging. Besides, IGFBP-3R expression was associated with tumor size, lymph node metastasis, differentiation, and TNM classification. Interestingly, we presented that the downregulation of IGFBP-3R was stage-dependent. In survival analysis, our findings showed that low levels of IGFBP-3R mRNA expression exhibited a close correlation with survival rate. Conclusion and implications: The findings of this study showed that the expression levels of IGFBP-3 and IGFBP-3R are valuable prognostic factors. Despite the potential of IGFBP-3, IGFBP-3R plays a significant role as a prognostic factor in gastric cancer. However, these findings need to be developed and confirmed by further studies.
کلیدواژه‌های انگلیسی مقاله Gastric cancer,IGFBP-3,IGFBP-3R,Prognostic factor,TNM classification.
نویسندگان مقاله | Amir Ansari
Department of Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.


| Ali Gheysarzadeh
Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.


| Ali Sharifi
Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Mohammad Reza Mofid


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2229
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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