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Acta Medica Iranica، جلد ۴۹، شماره ۱۱، صفحات ۷۰۱-۷۰۶
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عنوان انگلیسی Comparison of the Efficacy of Nifedipine and Hydralazine in Hypertensive Crisis in Pregnancy
چکیده انگلیسی مقاله Intravenous hydralazine is a commonly administered arteriolar vasodilator that is effective for hypertensive emergencies associated with pregnancy. Oral nifedipine is an alternative in management of these patients. In this study the efficacy of nifedipine and hydralazine in pregnancy was compared in a group of Iranian patients. Fifty hypertensive pregnant women were enrolled in the study. A randomized clinical trial was performed, in which patients in two groups received intravenus hydralazine or oral nifedipine to achieve target blood pressure reduction. The primary outcomes measured were the time and doses required for desired blood pressure achievement. Secondary measures included urinary output and maternal and neonatal side effects. The time required for reduction in systolic and diastolic blood pressure was shorter for oral nifedipine group (24.0±10.0 min) than intravenus Hydralazine group (34.8±18.8 min) (P≤0.016). Less frequent doses were required with oral nifedipine (1.2±0.5) compared to intravenus hydralazine (2.1±1.0) (P≤0.0005). There were no episodes of hypotension after hydralazine and one after nifedipine. Nifedipine and hydralazine are safe and effective antihypertensive drugs, showing a controlled and comparable blood pressure reduction in women with hypertensive emergencies in pregnancy. Both drugs reduce episodes of persistent severe hypertension. Considering pharmacokinetic properties of nifedipine such as rapid onset and long duration of action, the good oral bioavailability and less frequent side effects, it looks more preferable in hypertension emergencies of pregnancy than hydralazine.
کلیدواژه‌های انگلیسی مقاله Hydralazine,Hypertensive crisis,Nifedipine,Pre-eclampsia
نویسندگان مقاله زهرا رضایی | zahra rezaei
department of obstetrics amp;amp; gynecology, women hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه رحیمی شعرباف | fatemeh rahimi sharbaf
department of obstetrics amp;amp; gynecology, women hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مینو pourmojieb | mino pourmojieb
department of obstetrics amp;amp; gynecology, women hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

یاشار youefzadeh فرد | yashar youefzadeh fard
department of obstetrics amp;amp; gynecology, women hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منیژه متولیان | manijeh motevalian
department of pharmacology, razi institute for drug research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا خزاعی پور | zahra khazaeipour
research development center, imam khomeini hospital, health deputy of tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سارا اسماعیلی | sara esmaeili
department of obstetrics amp;amp; gynecology, women hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3823
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