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Iranian Journal of Microbiology، جلد ۱۶، شماره ۱، صفحات ۱۱۴-۱۲۳
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عنوان انگلیسی Association of polymorphisms in TLR3 and TLR7 genes with susceptibility to COVID-19 among Iranian population: a retrospective case-control study
چکیده انگلیسی مقاله Background and Objectives: Host genetic changes like single nucleotide polymorphisms (SNPs) are one of the main factors influencing susceptibility to viral infectious diseases. This study aimed to investigate the association between the host SNP of Toll-Like Receptor3 (TLR3) and Toll-Like Receptor7 (TLR7) genes involved in the immune system and susceptibility to COVID-19 in a sample of the Iranian population. Materials and Methods: This retrospective case-control study evaluated 244 hospitalized COVID-19 patients as the case group and 156 suspected COVID-19 patients with mild signs as the control group. The genomic DNA of patients was genotyped for TLR7 (rs179008 and rs179009) and TLR3 (rs3775291 and rs3775296) SNPs using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: A significant association between rs179008 SNP in the TLR7 gene and the susceptibility of COVID-19 was found between case and control groups. The AT genotype (Heterozygous) of TLR7 rs179008 A>T polymorphism showed a significant association with a 2.261-fold increased odds of COVID-19 (P=0.003; adjusted OR: 2.261; 99% CI: 1.117-4.575). In addition, a significant association between TC genotype of TLR7 rs179009 T>C polymorphism and increased odds of COVID-19 (P< 0.0001; adjusted OR: 6.818; 99% CI: 3.149-14.134) were determined. The polymorphism frequency of TLR3 rs3775291 and rs3775296 genotypes were not significantly different between the case and control groups (P> 0.004167). Conclusion: SNPs in TLR7 rs179008 and rs179009 genotypes are considered host genetic factors that could be influenced individual susceptibility to COVID-19. The SNPs in TLR3 (rs3775296 and rs3775291) showed no significant association with COVID-19 in Iranian population.
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نویسندگان مقاله | Masoud Parsania
Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Seyed Mahmood Seyed Khorrami
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Mandana Hasanzad
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran


| Negar Parsania
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Sina Nagozir
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Narges Mokhtari
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Hossein Mehrabi Habibabadi
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Azam Ghaziasadi
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran


| Saber Soltani
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran


| Ali Jafarpour
Amir-al-Momenin Medical and Educational Center, Gerash University of Medical Sciences, Gerash, Iran


| Reza Pakzad
Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran


| Seyed Mohammad Jazayeri
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4226
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