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Veterinary Research Forum، جلد ۱۵، شماره ۲، صفحات ۷۵-۸۲
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عنوان انگلیسی Cell proliferation and apoptosis in canine oral papillomatosis
چکیده انگلیسی مقاله This study was aimed at the evaluation of cell proliferation, p53 level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohisto-chemically demonstrated to carry a mutant p53 gene. Despite the mutation of p53 gene, the shift in the Bax/Bcl-2 ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspase-dependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Canine, p53, Papillomatosis, Proliferation
نویسندگان مقاله Emin Karakurt |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Nuvit Coskun |
Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Uğur Aydın |
Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Serpil Dağ |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Enver Beytut |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Veysel Soydal Ataseven |
Department of Virology, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Türkiye

Volkan Yılmaz |
Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Fırat Doğan |
Department of Virology, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Türkiye

Hilmi Nuhoğlu |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Celal Şahin Ermutlu |
Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Ayfer Yıldız |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

نشانی اینترنتی https://vrf.iranjournals.ir/article_709148_604d8dc822fca764141846af55a97a16.pdf
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