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Iranian Journal of Toxicology، جلد ۱۸، شماره ۱، صفحات ۶-۱۳
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عنوان انگلیسی Impact of Sodium Metabisulfite on Oxidative Stress, Hormones, and Reproductive Tissue in Female Wistar Rats
چکیده انگلیسی مقاله Background: Sodium metabisulfite is a frequently utilized food preservative. While it is generally acknowledged as safe, there have been certain apprehensions regarding its potential impacts. The study aims to investigate the effects of sodium metabisulfite on hormonal levels, ovarian and uterine histoarchitecture, and oxidative stress markers in Wistar rats.
Methods: Twenty-four adolescent female Wistar rats were randomly allocated into four groups (each with 6 rats): Group 1 (control) received 0.5ml normal saline, Group 2 was given 100 mg/kg sodium metabisulfite (NaMBS), Group 3 received 300 mg/kg NaMBS, and Group 4 was administered 500 mg/kg NaMBS. The administration was oral over 28 days, followed by euthanasia for tissue collection. Blood serum assessed follicle stimulating hormone (FSH) and luteinizing hormone (LH), while ovary and uterus tissue samples were taken for malondialdehyde (MDA) assays and histopathology. Histopathology involved Haematoxylin and Eosin (H&E) and Periodic Acid Schiff (PAS) staining.
Results: The administration of NaMBS at doses of 300mg/kg and 500mg/kg had a notable impact on hormone levels, particularly follicle stimulating hormone (FSH) and luteinizing hormone (LH). These doses also resulted in disrupted histoarchitecture and altered glycogen expression in ovaries and uteri, as observed in histological images. Furthermore, the highest NaMBS dose (500mg/kg) led to a significant increase in the oxidative stress marker malondialdehyde.
Conclusion: NaMBS affected FSH and LH levels, influencing ovarian and uterine structures. Disrupted structure and raised oxidative stress imply reproductive health risks. Further research is needed, including NaMBS's glycogen impact and FSH mechanisms.
 
کلیدواژه‌های انگلیسی مقاله Sodium metabisulfite, Food preservative, Hormonal levels, Ovary, uterus, Oxidative stress
نویسندگان مقاله | Nathaniel Amedu
Adeleke University Ede, Osun State, Nigeria


| Elizabeth Ajayi
Adeleke University Ede, Osun State, Nigeria
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-949-3&slc_lang=en&sid=1
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