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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۲، صفحات ۲۱۵-۲۲۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial
چکیده انگلیسی مقاله Objective: Despite an increasing number of studies, there is as yet no definite treatment developed for the coronavirus disease 2019 (COVID-19). In this clinical trial, we examined the efficacy of a novel herbal antiviral preparation in critically ill COVID-19 patients.Materials and Methods: A total number of 120 ICU-admitted patients with a diagnosis of COVID-19 pneumonia were recruited to the trial. Participants were equally randomized to receive either the novel antiviral preparation sublingually, for up to two consecutive weeks or till discharge, or placebo. Clinical and laboratory parameters as well as survival rates were compared between the two groups.Results: The cumulative incidence of death throughout the study period was 8.33% in the intervention group and 60% in the placebo group (risk ratio: 0.14; 95% confidence interval [CI], 0.05 to 0.32; p<0.001). On day 7, several parameters including white blood cells (WBCs) count, C-reactive protein, and SpO2 were improved for the treatment group compared with the placebo group (p-values of 0.05, 0.01, and <0.001, respectively).Conclusion: This preparation might be suggested as a potentially promising COVID-19 treatment.
کلیدواژه‌های انگلیسی مقاله Coronavirus, SARS-CoV-2, COVID-19, Treatment, ICU Hospitalization, Mortality rate
نویسندگان مقاله | Hossein Faramarzi
Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Ahmad Hosseinpour
Shimi Teb Salamat Co., Shiraz, Iran


| Amirhossein Sahebkar
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran


| Vahid Khaloo
Ali Asghar Hospital, Shiraz University of Medical Sciences, Shiraz, Iran


| Parisa Chamanpara
Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad Reza Heydari
Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Sajad Najafi
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Fatemeh Fotoohi Khankahdany
Shimi Teb Salamat Co., Shiraz, Iran


| Ahmad Movahedpour
Behbahan Faculty of Medical Sciences, Behbahan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_23259.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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