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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۲، صفحات ۲۲۹-۲۴۱
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عنوان انگلیسی Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial
چکیده انگلیسی مقاله Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.Materials and Methods: In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV1). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.Results: Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV1 was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.
کلیدواژه‌های انگلیسی مقاله Asthma, Nano-curcumin, Quality of life
نویسندگان مقاله | Shahrzad Mohammadzadeh Lari
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Amir Houshang Mohamadpour
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Davood Attaran
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahmodreza Jafari
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Omid Arasteh
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Emadzadeh
Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahnaz Mozdourian
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Soroush Attaran
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Zahra Javidarabshahi
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_22826.html
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