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Acta Medica Iranica، جلد ۴۹، شماره ۳، صفحات ۱۲۷-۱۳۰
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عنوان انگلیسی Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study
چکیده انگلیسی مقاله Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids. In this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. The control group were treated by perilesional surgical excision of keloids combined with topical silicone and the trial group were treated with adjuvant treatment of intralesional 5-Fluorouracil. All patients were examined and assessment was done by an independent observer. the data collected were analyzed by SPSS statistical software with using tables and χ square tests. 75% of the cases in the trial group were keloid free 21% have keloid partially improvement and 4% have keloid recurrence, compared to patients in the control group respectively: 43%, 35% and 22%, findings suggest that efficacy of 5-Fluorouracil combined with topical silicone used for the prevention of keloid is comparable to other modality. The lack of any serious side effects and the evidence of recurrence at one year of follow-up make this an effective tool for the prevention of keloids.
کلیدواژه‌های انگلیسی مقاله Keloid,Silicones,Administration, topical,Fluorouracil
نویسندگان مقاله ابراهیم حاتمی پور | ebrahim hatamipour
department of surgery and burn, yasuj university of medical sciences, yasuj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

سعادت محرابی | saadat mehrabi
department of surgery and burn, yasuj university of medical sciences, yasuj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

محسن حاتمی پور | mohsen hatamipour
department of surgery and burn, yasuj university of medical sciences, yasuj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

حمید رضا غفاریان شیرازی | hamid reza ghafarian shirazi
department of social medicine, faculty of medicine; yasuj university of medical sciences, yasuj, iran. and department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3709
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