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Acta Medica Iranica، جلد ۲۰۱۰، شماره ۱۰، صفحات ۲۸۳-۲۸۸
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عنوان انگلیسی Anti-mutagenic and Pro-apoptotic Effects of Apigenin on Human Chronic Lymphocytic Leukemia Cells
چکیده انگلیسی مقاله Diet can play a vital role in cancer prevention. Nowadays the scientists are looking for food materials which can potentially prevent the cancer occurrence. The purpose of this research is to examine anti-mutagenic and apoptotic effects of apigenin in human lymphoma cells. In present study human chronic lymphocytic leukemia (Eheb cell line) were cultured in RPMI 1640 (Sigma), supplemented with 10% fetal calf serum, penicillin-streptomycin, L-glutamine and incubated at 37 ºC for 2 days. In addition cancer cell line was treated by and apigenin and cellular vital capacity was determined by MTT assay. Then effect of apigenin in human lymphoma B cells was examined by flow cytometry techniques. The apigenin was subsequently evaluated in terms of anti-mutagenic properties by a standard reverse mutation assay (Ames test). This was performed with histidine auxotroph strain of Salmonella typhimurium (TA100). Thus, it requires histidine from a foreign supply to ensure its growth. The aforementioned strain gives rise to reverted colonies when expose to sodium azide as a carcinogen substance. During MTT assay, human chronic lymphocytic leukemia revealed to have a meaningful cell death when compared with controls (P
کلیدواژه‌های انگلیسی مقاله Antimutagenicity,antineoplastic agents,Leukemia
نویسندگان مقاله مهرداد هاشمی | mehrdad hashemi
department of genetics, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهدی نوری لنگ | mehdi nouri long
department of medicine, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ملیحه انتظاری | maliheh entezari
department of genetics, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شهره نفیسی | shohreh nafisi
department of chemistry, islamic azad university, central tehran branch, tehran, iran. and research institute for islamic and complementary medicine, iran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

حسین nowroozii | hossein nowroozii
research institute for islamic and complementary medicine, iran university of medical science, tehran, iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4049
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زبان مقاله منتشر شده en
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