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Iranian Journal of Medical Sciences، جلد ۴۹، شماره ۳، صفحات ۱۶۷-۱۷۵
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عنوان انگلیسی Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis
چکیده انگلیسی مقاله Background: The attentive management of rheumatoid arthritis (RA) has attracted particular attention. The German 7-joint Ultrasound (US-7) is the first scoring system that combines bone erosions and soft tissue lesions in a single composite scoring system. This study aimed to assess the correlation between US-7 and Disease Activity Score Using 28 Joint Counts (DAS28) in clinically active RA patients. The efficacy of a novel ultrasound score-based system, the US-9 score (joints assessed with US-7 plus knees), was also compared with the standard US-7 score.
Methods: All the RA patients referred to the outpatient rheumatology clinic of Ghaem Hospital, Mashhad, Iran, during 2019-2020 were included. 28 joints were clinically examined to calculate DAS28. Nine joints were assessed comprising the German US-7 plus knees using grayscale ultrasonography (GSUS) and power Doppler ultrasonography (PDUS). Retrieved data were analyzed by SPSS software, version 22. The Spearman Correlation test was used to find the correlation between DAS28 and ultrasonographic findings. The statistical significance level was set at P<0.05. 
Results: This study was composed of thirty-five RA patients with a mean age of 49.1±12.0 years. US-7 synovitis scores in GSUS and PDUS were significantly correlated with DAS28 (P=0.02, r=0.38 and P=0.003, r=0.48, respectively). US-9 synovitis scores in GSUS and PDUS were also significantly correlated with DAS28 (P=0.003, r=0.49 and P=0.006, r=0.45, respectively). The synovitis score measured by GSUS was significantly correlated with the GSUS knee synovial score (P=0.01, r=0.42).
Conclusion: Ultrasound assessment of large joints such as knees can be an effective approach to determining RA severity. However, it can be proposed that adding more involved joints into the sonographic assessment does not necessarily provide a better clinical correlation.
کلیدواژه‌های انگلیسی مقاله Arthritis, rheumatoid, Ultrasonography, Joints, Ultrasonography, doppler
نویسندگان مقاله Sahar Ebadati |
Department of Radiology, Medical Imaging Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Sahebari |
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Amir Mahmoud Ahmadzadeh |
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Emadzadeh |
Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Farzaneh Khoroushi |
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hedieh Ragati Haghi |
Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02215, USA

Ramesh Giti |
Department of Radiology, Medical Imaging Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Behzad Aminzadeh |
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_49670_48bab2ed0f4cde8bad5f219babc332d4.pdf
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