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Cell Journal، جلد ۲۶، شماره ۲، صفحات ۹۸-۱۱۱
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عنوان انگلیسی Review on Kidney-Liver Crosstalk: Pathophysiology of Their Disorders
چکیده انگلیسی مقاله Kidney-liver crosstalk plays a crucial role in normal and certain pathological conditions. In pathologic states, both
renal-induced liver damage and liver-induced kidney diseases may happen through these kidney-liver interactions.
This bidirectional crosstalk takes place through the systemic conditions that mutually influence both the liver and
kidneys. Ischemia and reperfusion, cytokine release and pro-inflammatory signaling pathways, metabolic acidosis,
oxidative stress, and altered enzyme activity and metabolic pathways establish the base of this interaction between
the kidneys and liver. In these concomitant kidney-liver diseases, the survival rates strongly correlate with early
intervention and treatment of organ dysfunction. Proper care of a nephrologist and hepatologist and the identification
of pathological conditions using biomarkers at early stages are necessary to prevent the complications induced by this
complex and potentially vicious cycle. Therefore, understanding the characteristics of this crosstalk is essential for
better management. In this review, we discussed the available literature concerning the detrimental effects of kidney
failure on liver functions and liver-induced kidney diseases.
کلیدواژه‌های انگلیسی مقاله Cirrhosis, Hepatitis, Liver failure, Nephropathy, Renal failure
نویسندگان مقاله Niloofar Khoshdel Rad |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Zahra Heydari |
World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov University, Moscow, Russia

Amir Hossein Tamimi |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Ensieh Zahmatkesh |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Anastasia Shpichka |
World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov University, Moscow, Russia

Maryam Barekat |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Peter Timashev |
World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov University, Moscow, Russia

Nikoo Hossein-khannazer |
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Moustapha Hassan |
Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Massoud Vosough |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

نشانی اینترنتی https://www.celljournal.org/article_709642_b727cd53569dfe43403478f8cde3ecda.pdf
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