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Journal of Craniomaxillofacial Research، جلد ۱۰، شماره ۴، صفحات ۱۶۱-۱۶۵
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عنوان انگلیسی Comparing Salivary Mir-125 And Mir-30 Expression In Oral Squamous Cell Carcinoma To Healthy Individuals
چکیده انگلیسی مقاله Introduction: OSCC (Oral squamous cell carcinoma) accounts for approximately 90% of all oral malignancies and is usually diagnosed at advanced stages. This study investigates changes in miR-125 and miR-30 expression in relation to the clinical findings of oral cavity cancer and their possible use as an early diagnostic tool. Method and Material: A population of 30 individuals with oral squamous cell carcinoma and 30 healthy individuals was studied, and the mean age of two groups were compared using a t-test, with no significant difference found in terms of age so age will not be an interfering factor in this study. The levels of these two biomarkers (miR-125 and miR-30) were measured and evaluated using real-time PCR technique. Results: After evaluating the results of real-time PCR technique, it was found that miR-125 was positive in 25 out of 30 patients, while it was positive in 5 out of 30 healthy individuals (p-value ≤0.001). miR-30 was a positive biomarker in 10 out of 30 patients. The amount of this biomarker in the group of healthy individuals was 26 out of 30 (p-value < 0.001). CONCLUSION: The miR-125 profile is upregulated in the saliva of OSCC cases, whereas the miR-30 profile is downregulated in the aforementioned patients compared with the healthy group. Therefore, measurement of miR-125 and miR-30 may be a protentional diagnostic test to identify OSCC. We suggest more extensive studies with a larger sample size to support this claim. Keywords: oral squamous cell carcinoma, miR-125, miR-30, biomarker 
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نویسندگان مقاله | Naghmeh Bahrami
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Marziyeh Poorahmad
Department of Genetic, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Farzaneh Hosseini
Department of Microbiology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Farnoush Mohammadi
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.


| Amir Rasouli
Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.


| Mona Mohajeri Tehrani
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Masoume Farhangiyan
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Abdolreza Mohamadnia
Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Bheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی https://jcr.tums.ac.ir/index.php/jcr/article/view/464
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