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Iranian Journal of Biotechnology، جلد ۲۲، شماره ۱، صفحات ۹۶-۱۰۳
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عنوان انگلیسی Efficient Induction of Apoptosis in Lung Cancer Cells Using Bismuth Sulfide Nanoparticles
چکیده انگلیسی مقاله Background: The use of nanomaterial-based radiosensitizers to improve the therapeutic ratio has gained attraction in
radiotherapy. Increased radiotoxicity applied to the tumor region may result in adverse impact on the unexposed normal
cells to the radiation, a phenomenon known as radiation-induced bystander effect (RIBE).
Objectives: This study aimed to investigate the effect of Bi2S3@BSA nanoparticles (NPs) as radiosensitizers on the
enhancement of bystander response in non-irradiated cells.
Materials and Methods: Lung carcinoma epithelial cells were exposed to 6 MV x-ray photons at different doses of 2 and
8 Gy, with and without Bi2S3@BSA NPs. The irradiated-cell’s conditioned medium (ICCM) was collected and incubated
with MCR-5 human fetal lung fibroblasts.
Results: This study showed that ICCM collected from 2-Gy-irradiated A549 cells in the presence of Bi2S3@BSA NPs
reduced the cell viability of MCR-5 bystander cells more than ICCM collected from irradiated cells without NPs (P<0.05),
whereas such a difference was not observed after 8-Gy radiation. The mRNA expression of the BAX and XPA genes, as
well as the cell death rate in MCR-5 bystander cells, revealed that the Bi2S3@BSA NPs significantly improved bystander
response at 2-Gy (P<0.05), but the efficacy was not statistically significant after 8-Gy Irradiation.
Conclusion: The results indicated that the presence of NPs did not affect bystander response enhancement at higher
concentrations. These findings highlighted the potential use of radiation-enhancing agents and their benefits in radiotherapy techniques with high doses per fraction.
کلیدواژه‌های انگلیسی مقاله Bismuth Nanoparticles, Bystander Effect, Lung cancer, Radiation therapy
نویسندگان مقاله Leila Nasehi |
Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Hamed Rezaeejam |
Department of Radiology, School paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

Hossein Danafar |
Zanjan pharmaceutical Biotechnology Research center, Zanjan University of Medical Sciences, Zanjan, Iran

Parvin Mirzaghavami |
Department of Radiology, School paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

Ali Mohammadi |
Zanjan pharmaceutical Biotechnology Research center, Zanjan University of Medical Sciences, Zanjan, Iran

Mahda Delshad |
Department of Medical Laboratory, School paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran

Massoud Vosough |
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

نشانی اینترنتی https://www.ijbiotech.com/article_189423_51a0dea8f7e111ef113b8670e077f9ce.pdf
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