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Acta Medica Iranica، جلد ۴۷، شماره ۵، صفحات ۳۵۳-۳۵۷
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چکیده فارسی مقاله
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عنوان انگلیسی On-Demand Treatment of Premature Ejaculation with Citalopram: A Randomized Double-Blind Study
چکیده انگلیسی مقاله As the most common male sexual disorder premature ejaculation (PE), also referred to as early ejaculation (EE) or rapid ejaculation (RE), affects 30%-40% of sexually active men. Despite the limited number of available studies comparing the efficacy of selective serotonin re-uptake inhibitors (SSRI) they have been thought to have beneficial effects for the treatment of patients with PE. In the present study, we assessed the efficacy of on-demand use of citalopram, in the treatment of premature ejaculation. A randomized double blind study of fixed dose on-demand use of citalopram was performed in Roozbeh Psychiatry Hospital, Tehran University of Medical Sciences. The sample was consisted of 80 married patients diagnosed with PE according to Diagnostic and Statistical Manual of Mental Disorders. The patients were randomly assigned to two groups: group 1 consisting of 42 patients received 20mg citalopram, and group 2 consisting of 38 patients received placebo four hours before intercourse for a 4-week treatment course. The effects of drug on the ejaculatory function in each group were assessed by the intravaginal ejaculation latency time (IELT), and the Chinese Index of Premature Ejaculation (CIPE) before and at the end of treatment course. The mean IELT increased from 66.78±36.94 to 80.85±43.05 seconds in group 1 and from 63.44±33.16 to 65.71±34.26 seconds in group 2 ( P = 0.000). Mean CIPE score increased 1.14±1.04 and 0.52±0.50 in group 1 and 2 respectively ( P = 0.002). The patients treated with on demand citalopram showed significantly greater improvement in IELT and CIPE score compared to the patients receiving placebo. It seems that citalopram may be an effective treatment of premature ejaculation with on-demand usage. However further studies are warranted.
کلیدواژه‌های انگلیسی مقاله SSRI,citalopram,placebo,premature ejaculation
نویسندگان مقاله وحید فرنیا | vahid farnia
department of psychiatry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فیروزه رییسی | firoozeh raisi
department of psychiatry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد قاسم محسنی | mohmmad ghasem mohseni
department of urology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

داود atharikia | davood atharikia
department of urology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا غفوری | zahra ghafuri
department of psychiatry, roozbeh hospital, psychiatry and psychology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3606
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