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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۵، صفحات ۵۴۳-۵۵۱
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عنوان انگلیسی Therapeutic potential of virgin coconut oil in mitigating sodium benzoate- model of male infertility: Role of Nrf2/Hmox-1/NF-kB signaling pathway
چکیده انگلیسی مقاله Objective(s): Male infertility is a major public health issue due to increased prevalence, so there is an urgent need for a therapeutic solution. The search for a natural dietary substance that could modulate redox balance and inflammation and protect testicular function is in demand. Virgin Coconut Oil (VCO) has found use in the treatment of diabetes, and cancer owing to the presence of polyphenols. However, there is a dearth of information on its effect on testicular toxicity. The present study investigated VCO as a possible treatment for testicular toxicity in the Sodium Benzoate (SB) model of male infertility by evaluating the oxidative and inflammatory status, circulating hormonal levels, and key sperm indices.Materials and Methods: Twenty adult male rats were randomly assigned to four groups of 5 rats each and were treated with normal saline, sodium benzoate, sodium benzoate+5% VCO, and sodium benzoate+15% VCO for 30 days respectively. Biochemical analysis of reproductive hormones was assessed. Sperm parameters assessed include sperm function tests and sperm kinematics. One-way analysis of variance (ANOVA) followed by post hoc Tukey tests was performed.Results: 5% VCO reverts the deranged serum reproductive hormones caused by sodium benzoate. 5% VCO was more potent as an antioxidant and anti-inflammatory treatment than 15% VCO. However, both doses prevented SB’s effect on the sperm function test and kinematics.Conclusion: VCO-supplemented diet can ameliorate SB-induced testicular toxicity by inhibiting its mechanisms of toxicity that are related to oxidative stress, apoptosis, and inflammation.
کلیدواژه‌های انگلیسی مقاله Food additives, Reproductive Hormones, Sperm analyses, Testicular toxicity, virgin coconut oil
نویسندگان مقاله | Ayodeji Ajibare
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Lead City University Ibadan, Oyo State, Nigeria


| Olabode Akintoye
Department of Physiology, Ekiti-State University, Ado-Ekiti, Ekiti-State, Nigeria


| Moshood Folawiyo
Department of Physiology, Ekiti- State University, Ado-Ekiti, Ekiti-State, Nigeria


| Kabirat Babalola
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Lead City University Ibadan, Oyo State, Nigeria


| Olaposi Omotuyi
Department of Pharmacology& Toxicology, College of Pharmacy, Afe Babalola University, Ado-Ekiti, Ekiti-State, Nigeria


| Busayo Oladun
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Lead City University Ibadan, Oyo State, Nigeria


| Kafilat Aransi-ola
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Lead City University Ibadan, Oyo State, Nigeria


| Lukman Olayaki
Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin. Nigeria


| Adeyemi Fatai Odetayo
Federal University of Health Sciences, Ila Orangun, Osun State, Nigeria
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23654.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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