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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۵، صفحات ۶۴۰-۶۴۶
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عنوان انگلیسی Effects of Crocus sativus and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by PQ aerosol in rats
چکیده انگلیسی مقاله Objective(s): The effects of Crocus sativus, safranal, and pioglitazone on aerosolized paraquat (PQ)-induced systemic changes were examined.  Materials and Methods: Control (Ctrl) and PQ groups of rats were exposed to saline or PQ (27 and 54 mg/m3, PQ-L and PQ-H) aerosols eight times on alternate days. Nine PQ-H groups were treated with dexamethasone (0.03 mg/kg/day, Dexa), two doses of C. sativus extract (20 and 80 mg/kg/day, CS-L and CS-H), safranal (0.8 and 3.2 mg/kg/day, Saf-L and Saf-H), pioglitazone (5 and 10 mg/kg/day, Pio-L and Pio-H), and the combination of low dose of the pioglitazone and extract or safranal (Pio + CS and Pio + Saf) after the end of PQ exposure. Results: Interferon-gamma (INF-γ), interleukin 10 (IL-10), superoxide dismutase (SOD), catalase (CAT), and thiol serum levels were reduced, but tumor necrosis factor (TNF-α), malondialdehyde (MDA), and total and differential WBC were increased in both PQ groups (P<0.05 to P<0.001). All measured variables were improved in all treated groups (P<0.05 to P<0.001). The effects of high dose of C. sativus and safranal on measured parameters were higher than dexamethasone (P<0.05 to P<0.001). The effects of  Pio + CS and Pio + Saf treatment on most variables were significantly higher than three agents alone (P<0.05 to P<0.001).Conclusion: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.
کلیدواژه‌های انگلیسی مقاله Crocus sativus, Inflammation, Oxidative stress, Paraquat, Pioglitazone, Safranal
نویسندگان مقاله | Arghavan Memarzia
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Saffron InstituteUniversity of Torbat Heydarieh, Torbat Heydarieh, Iran


| Zahra Ghasemi
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Fatemeh Amin
Physiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Zahra Gholamnezhad
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Hossein Boskabady
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23813.html
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