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Basic and Clinical Neuroscience، جلد ۱۵، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی The Pattern of Neuroinflammatory miRNAs, C-Reactive Protein, and Alanine Aminotransferase During Hospitalization In Recovered or Not-Recovered COVID-19 Patients
چکیده انگلیسی مقاله
Background: Our aim was to investigate the expression of miRNAs, C-reactive protein as a blood inflammation marker, and alanine aminotransferase as a tissue inflammation marker in recovered and not-recovered COVID-19 patients.
Methods: This cross-sectional project was done in three medical center of Iran from December to March, 2021. Generally, a total of 20 confirmed cases of COVID-19 with grade III and 20 healthy subjects were enrolled in the study. Then, the neuroinflammatory expression of miRNAs (miR-199, miR-203, and miR-181), C-reactive protein, and alanine aminotransferase were investigated during hospitalization from week 0 to week 2.
Results: In not-recovered COVID-19 subjects, the expression of miR-199, miR-203, and miR-181 were decreased and the levels of C-reactive protein and alanine aminotransferase were increased during hospitalization. Conversely, in recovered COVID-19 subjects, the relative expression of miR-199, miR-203, and miR-181 were increased and the levels of C-reactive protein and alanine aminotransferase were decreased during hospitalization.
Conclusions:  The expression pattern of neuroinflammatory miRNAs is depends on whether the COVID-19 patient is recovering or deteriorating. Their expression is down-regulated in not-recovered COVID-19 patients and up-regulated in recovered COVID-19 patients.
کلیدواژه‌های انگلیسی مقاله miRNAs, COVID-19, Neuroinflammatory, Hospitalization
نویسندگان مقاله | Reza Keikha
Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.


| Seyed Mohammad Hashemi-Shahri
Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.


| Ali Jebali
Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-3342-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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