این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Neuroscience، جلد ۱۵، شماره ۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients with Bipolar Disease
چکیده انگلیسی مقاله
Background and Objectives: Antioxidants prevent the progression of neuropsychiatric disorders, such as bipolar disorder (BD). Omega-3 fatty acid supplementation helps prevent lipid peroxidation and improve antioxidant status. This study aims to investigate the effect of omega-3 supplementation on serum levels of antioxidant status in patients with BD.
Methods: In this study, 28 patients with BD received an omega-3 fatty acid supplement (2 g/daily) while the other 28 patients received edible paraffin oil (2 g/daily) for 60 days. The activities of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were evaluated in pre-intervention and post-intervention.
Results: The results showed that omega-3 supplementation increased the activities of SOD (12.94 ± 3.84 U/mL vs 17.72 ± 3.59 U/mL) and CAT (5.08 ± 1.61 nmol/min/mL vs 6.43 ± 1.33 nmol/min/mL) in post-intervention compared to pre-intervention (P = 0.001). The results also showed that omega-3 supplementation increased the activities of SOD (17.72 ± 3.59 U/mL vs 13.79 ± 3.12 U/mL) and CAT (6.43 ± 1.33 nmol/min/mL vs 4.89 ± 1.45 nmol/min/mL) compared to the control group in post-intervention (P = 0.001). Omega-3 supplementation did not have significant effects on the serum concentration of total antioxidant capacity (TAC) compared to pre-intervention (P = 0.373) and control group (P = 0.604). 
Conclusion: Omega-3 supplementation increased the activities of SOD and CAT and may decrease the progression of disease via increasing antioxidant status.
کلیدواژه‌های انگلیسی مقاله Antioxidant capacity, Bipolar disease (BD), Catalase (CAT), Omega-3
نویسندگان مقاله | Dina Gholipour
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.


| Mansour Shahraki
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.


| Mohsen Saravani
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.


| Abolfazl Payandeh
Community Nursing Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.


| Hadi Eslahi
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-4292-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات