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Acta Medica Iranica، جلد ۴۶، شماره ۶، صفحات ۴۵۷-۴۶۰
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عنوان انگلیسی IDENTIFICATION OF ACROSOME AS THE MAIN ANTIGEN OF THE SPERM CELLS PROVOKING AUTOANTIBODIES IN VASECTOMIZED IRANIAN MEN
چکیده انگلیسی مقاله Vasectomy is one of the extensively used methods of contraception in family planning programs. Antisperm antibodies (ASA) develop after vasectomy which can result in auto-immune male infertility. The precise sperm antigens involved in the autoimmune response are still poorly defined, therefore we determined the circulating ASA and identified relevant sperm antigens based on localization of binding sites of ASA to sperm cell antigens, using a rapid, inexpensive and clinically relevant assay in vasectomized men. Results showed that 2.5% of men had ASA at the time of vasectomy, whereas 53.5% of the study population subsequently developed ASA. The numbers of men with circulating ASA increased significantly for the first three months after vasectomy. These antibodies were distinguishable into three groups based on their bindings to different sites of sperm cell antigens including against acrosome and tail in 67.56% and 10.8%, respectively; 21.6% of subjects had antibody to the other parts of the sperm cell antigens. The results of this study are discussed in terms of an autoimmune response against sperm antigens and development of ASA.
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نویسندگان مقاله m نوروزی | m nowroozi
department of urology, imam khomeini hospital, school of medicine, tehran university of medicine sci

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a کیهانی | a keyhani
department of immunology, school of medicine, tehran university of medicine sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

m آیتی | m ayati
department of urology, imam khomeini hospital, school of medicine, tehran university of medicine sci

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3519
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زبان مقاله منتشر شده en
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