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Research Journal of Pharmacognosy، جلد ۱۱، شماره ۲، صفحات ۱۹-۲۵
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عنوان انگلیسی Evaluation of Wound Healing and Cytotoxic Activities of Anacardic Acid (13:0) Isolated from Pistacia vera Hull Extract
چکیده انگلیسی مقاله Background and objectives: Pistacia vera fruit is a popular nut belonging to Anacardiaceae family. Traditionally, the hulls have been used as herbal remedies for treatment of oral and skin wounds,peptic ulcers and hemorrhoids. Methods: In this study, anacardic acid (13:0) was elucidated by EI-MS, FTIR, 1D-NMR and 2D-NMR data analysisfrom active fraction. Cytotoxic activity was assessed against normal NIH/3T3 cells, and several cancerous human cells, including human breast cancer (MCF-7), hepatocarcinoma (HepG-2) and gastric cancer (MKN-45) using MTT assay. The wound healing activity of this compound was evaluated using in vitro scratch-wound healing assay on NIH/3T3 cells. Results: Anacardic acid (13:0) was toxic at the concentrations tested against all cell lines (6.25-100 µg/mL). Theselectivity index showed no selective cytotoxicity (SI< 2); however, anacardic acid (13:0) revealed significant wound healing effects through the migration of NIH/3T3 cells at the concentrations of 1.25-5 µg/mL. Conclusion: These results suggested that anacardic acid (13:0) from P. verahull has cytotoxic activity on human cancer cell lines and can also be useful as a bioactive molecule in wounds treatment. However, more in vitro and in vivo studies need to be done to confirm the efficacy and cytotoxicity of anacardicacid (13:0).
کلیدواژه‌های انگلیسی مقاله Anacardic acid, Cytotoxicity, Pistacia vera, Wound
نویسندگان مقاله Parisa Sarkhail |
Medicinal Plants Research Center, The Institute of Pharmaceutical Sciences (TIPS), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Ghazal Hashemi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Effat Souri |
Department of Medicinal Chemistry; Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_189473_5b577bed096bad5e5f5b298dbe812008.pdf
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