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Research Journal of Pharmacognosy، جلد ۱۱، شماره ۲، صفحات ۳۷-۴۶
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عنوان انگلیسی Antimycobacterial Activity and Brine Shrimp Toxicity of Wild Mushrooms Used by Communities in Southern Tanzania
چکیده انگلیسی مقاله Background and objectives: Several wild mushroom species occur in southern Tanzania and are used as food by the local tribes. Experience shows that some of them could contain phytochemical compounds with therapeutic potential for treating various diseases. This study aimed to evaluate wild mushrooms used by indigenous communities living near the Selous- Niassa corridor in Namtumbo district, in Southern Tanzania for safety and antimycobacterial activity. Methods: Wild mushroom samples were collected randomly during the wet season and extracted by cold maceration. Dried extracts were evaluated for safety using the brine shrimp lethality test and for antimycobacterial activity using a twofold microdilution method against non-pathogenic Mycobacterium madagascariense, Mycobacterium indicus pranii, and Mycobacterium aurum. Results: The mushroom extracts exhibited a good safety profile against brine shrimp larvae with LC50 values ranging from 20.28 µg/mL (moderately toxic) to 465.97 µg/mL (nontoxic). The extracts exhibited variable antimycobacterial activity against M. madagascariense, M. indicus pranii, and M. aurum with minimum inhibitory concentrations (MIC) between 0.78 and 12.5 mg/mL against M. madagascariense, 0.098 and 6.25 mg/mL against M. indicus pranii and 1.25 and 2.5 mg/mL against and M. aurum. Nineteen wild mushroom species (59.4%, n = 32) exhibited antimycobacterial activity against all three mycobacterial species used. Conclusion: Preliminary investigation has provided evidence that some of the mushrooms locally available are not toxic. Some of these mushrooms have the potential to yield antimicobacterial active compounds. Further studies to determine the therapeutic and nutritional value of these mushrooms are needed.
کلیدواژه‌های انگلیسی مقاله anti-mycobacterial, brine shrimp lethality test, Therapeutic potential, wild mushrooms
نویسندگان مقاله Michael Qwarse |
Department of Natural Products Development and Formulations, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Mainen Julius Moshi |
Department of Clinical Pharmacology and Therapeutics, Hubert Kairuki Memorial University, 70 Chwaku Street, Regent Estate, Mikocheni, Dar es Salaam, Tanzania.

Matobola Joel Mihale |
Department of Physical and Environmental Sciences, Faculty of Science, Technology and Environmental Studies, The Open University of Tanzania, Dar es Salaam, Tanzania.

Alphonce Ignace Marealle |
Department of Clinical Pharmacy & Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Ramadhani Selemani Omari Nondo |
Department of Biological and Preclinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Joseph Sempombe |
Department of Medicinal Chemistry, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Veronica Mugoyela |
Kampala International University in Tanzania, Dar es Salaam, Tanzania.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_192336_3ef3817c684b5794ac491de24b6ad1ce.pdf
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