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Iranian Journal of Psychiatry، جلد ۱۹، شماره ۲، صفحات ۲۳۵-۲۴۳
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عنوان انگلیسی Auditory Steady-State Evoked Potentials in Post Traumatic Stress Disorder: Introduction of a Potential Biomarker
چکیده انگلیسی مقاله Objective: The lack of steady-state evoked potential (SSEP) studies on post-traumatic stress disorder (PTSD) has led to undiscovered useful information about the pathophysiology of the disorder. Thus, we explored SSEP patterns in PTSD patients during a stop-signal task to disclose possible impairments in these informative brain potentials. Method: 25 adult patients with PTSD and 25 healthy adults participated in this research. Subjects were assessed with electroencephalography while the tone signal stimuli at 40 Hz were used to evoke SSEPs and subjects performed a stop-signal task. The amplitude and phase of SSEPs were then computed in different brain regions. The subjects were also evaluated using the Mississippi PTSD questionnaire. Appropriate statistical methods such as repeated measure ANOVA were used to compare the two groups, and the correlation between SSEPs and clinical symptoms was assessed using Pearson correlation analysis. Results: Patients showed considerably poorer performance in the cognitive task (P < 0.01), accompanied by raised SSEP phase and amplitude in the anterior and midline regions compared to healthy controls (P < 0.05). The Mississippi total score was positively correlated with the SSEP amplitude in the midline region (r = 0.62, P < 0.05). Furthermore, based on ROC analysis, the SSEP amplitude in the midline region provided an excellent AUC value (AUC = 0.850) for distinguishing patients with PTSD from normal subjects. Conclusion: Current findings suggest that abnormalities in the anterior and midline cortical neural networks are involved in the pathophysiology of PTSD. Importantly, midline abnormalities may provide a clinically-relevant measure for researchers wishing to assess the use of biomarkers for early diagnosis of PTSD as well as to evaluate new therapeutic and management approaches in the treatment of PTSD.
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نویسندگان مقاله | Gila Pirzad Jahromi
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran.


| Hossein Gharaati Sotoudeh
Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Romina Mostafaie
Department of Psychology, Faculty of Psychology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.


| Ali Khaleghi
Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی https://ijps.tums.ac.ir/index.php/ijps/article/view/3389
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