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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۶، صفحات ۶۵۷-۶۷۰
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عنوان انگلیسی Novel drugs affecting diabetic peripheral neuropathy
چکیده انگلیسی مقاله Diabetic peripheral neuropathy (DPN) poses a significant threat, affecting half of the global diabetic population and leading to severe complications, including pain, impaired mobility, and potential amputation. The delayed manifestation of diabetic neuropathy (DN) makes early diagnosis challenging, contributing to its debilitating impact on individuals with diabetes mellitus (DM). This review examines the multifaceted nature of DPN, focusing on the intricate interplay between oxidative stress, metabolic pathways, and the resulting neuronal damage. It delves into the challenges of diagnosing DN, emphasizing the critical role played by hyperglycemia in triggering these cascading effects. Furthermore, the study explores the limitations of current neuropathic pain drugs, prompting an investigation into a myriad of pharmaceutical agents tested in both human and animal trials over the past decade. The methodology scrutinizes these agents for their potential to provide symptomatic relief for DPN. The investigation reveals promising results from various pharmaceutical agents tested for DPN relief, showcasing their efficacy in ameliorating symptoms. However, a notable gap persists in addressing the underlying problem of DPN. The results underscore the complexity of DPN and the challenges in developing therapies that go beyond symptomatic relief. Despite advancements in treating DPN symptoms, there remains a scarcity of options addressing the underlying problem. This review consolidates the state-of-the-art drugs designed to combat DPN, highlighting their efficacy in alleviating symptoms. Additionally, it emphasizes the need for a deeper understanding of the diverse processes and pathways involved in DPN pathogenesis.
کلیدواژه‌های انگلیسی مقاله Diabetic peripheral- neuropathy, Hyperglycemia, Molecular mechanism, Neuropathic pain, Quality of life, Therapeutic targets
نویسندگان مقاله | Dalia O. Saleh
Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 12622, Egypt


| Ahmed Sedik
Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 12622, Egypt
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23892.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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