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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۶، صفحات ۶۷۸-۶۸۴
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عنوان انگلیسی Alpha-pinene alleviates CCl4-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis
چکیده انگلیسی مقاله Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory and apoptotic factors in the kidneys and testes of rats treated with CCl4.Materials and Methods: CCl4 was injected intraperitoneally (IP) at a dose of 2 ml/kg (twice a week for six weeks). Alpha-pinene (50 mg/kg/day, IP) was also treated during the same period. Results: CCl4 increased the level of malondialdehyde (P<0.01 in the kidney and P<0.001 in the testis) and nitric oxide (P<0.001 in the kidney and P<0.01 in the testis) and decreased the levels of glutathione (P<0.05) in the kidneys and testicles of rats. CCl4 also reduced the catalase enzyme activity in the kidneys (P<0.05) but did not affect its activity in the testis. In addition, CCl4 enhanced the mRNA expression of TNF-α (P<0.01), nuclear factor-κB (P<0.05), and Bax (P<0.05 in the kidney and P<0.01 in the testis) and decreased the expression of Bcl-2 (P<0.05) in both organs. Alpha-pinene prevented all the mentioned changes, but it did not influence the expression of Bcl-2 in the kidneys of rats receiving CCl4. Conclusion: Alpha-pinene may have the potential to prevent renal and testicular diseases by strengthening the antioxidant system in the kidneys and testis, and inhibiting oxidative/nitrosative stress, inflammation, and apoptosis caused by CCl4.
کلیدواژه‌های انگلیسی مقاله Alpha-pinene, bcl-2-Associated X Protein, Inflammation, Kidney, Oxidative stress, Testis
نویسندگان مقاله | Fatemeh Noroozi
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran


| Masoumeh Asle Rousta
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran


| Rahim Amini
Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran


| Zeinab Sahraeian
Nanobiotechnology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23896.html
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