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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۶، صفحات ۶۹۵-۷۰۵
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عنوان انگلیسی Design and fabrication of alginate hydrogel nanohybrid as a promising cancer treatment
چکیده انگلیسی مقاله Objective(s): Basal cell carcinoma (BCC) is the most common form of skin cancer and the most frequently occurring form of all cancers, affecting sun-exposed areas like the face. Surgery is the main treatment, focusing on safe and minimally invasive methods for better outcomes. Technology has enabled the development of artificial skin substitutes for tissue repair. Tissue engineering uses scaffolds to create functional replacements. This project aims to create an alginate-based hydrogel with PEG-coated gold nanoparticles. Materials and Methods: The project extensively explored the modification of alginate hydrogels with PEG-coated gold nanoparticles, involving the synthesis of gold nanoparticles, their integration with the polymer, and the subsequent preparation of the concentrated hybrid hydrogel. Utilizing various physicochemical techniques, such as UV-visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential analysis, scanning electron microscopy, and Fourier transform infrared spectroscopy, the fabrication process was optimized and characterized. Results: The successful synthesis of the hybrid biomaterial was achieved through robust and highly reproducible methods. The MTT assay results offered valuable insights into the biocompatibility and safety of the PEG-coated gold nanoparticle-loaded alginate-based films. The incorporation of PEG-coated gold nanoparticles allowed for potential drug loading on the nanoparticle surface and, consequently, within the hydrogel. Cellular assays were conducted to assess the potential applications of this novel biomaterial. Conclusion: The addition of polyethylene glycol made it possible to load different drugs onto the gold nanoparticles and also within the hydrogel. This makes it a promising choice for potential uses in tissue engineering.
کلیدواژه‌های انگلیسی مقاله Alginate hydrogel, Cancer Treatment, Gold colloid, Nanostructures, Skin neoplasms
نویسندگان مقاله | Fatemeh Sadat Ajayebi
Department of biomedical engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran


| Nahid Hassanzadeh Nemati
Department of biomedical engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran


| Alireza Hatamirad
Department of biomedical engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran


| Mahrad Ghazli
Department of biomedical engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran


| Neda Attaran
Department of Medical Nanotechnology, Applied Biophotonics Research Center, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23881.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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