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Archives of Anesthesiology and Critical Care، جلد ۱۰، شماره ۲، صفحات ۱۲۵-۱۳۰
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عنوان انگلیسی Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study
چکیده انگلیسی مقاله Background: In the majority of cases, the treatment method for Cleft lip is surgery. Providing adequate pain control during and after surgery for children, is too important. Also, different methods are used for pain relief like analgesic prescription and nerve block and different adjuvants can be added to anesthetics to reduce pain. Aims: This trial was aimed to compare the analgesic effect of Bupivacaine with or without dexmedetomidine or dexamethasone for cleft lip surgery. Methods: This study is a prospective, double-blinded, randomized trial which conducted on 75 pediatrics, aged between 3 to 10 months, who needed unilateral cleft lip surgery. Patients were divided into 3 groups (n=25 in each group). Children in group A, were given a combination of bupivacaine and 0.5 µg/kg of dexmedetomidine, those in group B, 0.1 mg/kg of dexamethasone as an adjuvant to bupivacaine, and in group C, plain 1 cc of bupivacaine 0.5% was injected in the operation site. Outcomes were assessed via FLACC and WATCHA scores. Results: The mean age among children was 4.3 ±1.29 months and mean weight was 6.3± 1.09 kg. Pain score and frequency of analgesic request intra and post-operation in group A was lower than others (p<0.0001). Also, FLACC and WATCHA scores were significantly lower in group A (p<0.0001) and parental and surgeon satisfaction was higher in group A (p<0.05). Conclusion: Our study showed that, dexmedetomidine as an adjuvant to bupivacaine 0.5% is more effective to improve the analgesia, in children who underwent unilateral cleft lip surgery.
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نویسندگان مقاله | Sedighe Shahhosseini
Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Mohammad Montasery
Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Iman Raeisi
Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Amir Shafa
Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Mohammad Omid
Department of Pediatric Surgery, Surgery Research Center, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Mehrdad Memarzadeh
Department of Pediatric Surgery, Surgery Research Center, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.


| Yasaman Borghei
Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
نشانی اینترنتی https://aacc.tums.ac.ir/index.php/aacc/article/view/760
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