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Acta Medica Iranica، جلد ۴۵، شماره ۶، صفحات ۴۸۷-۴۹۲
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عنوان انگلیسی EVALUATION OF IL1-α AND TNF-α SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION
چکیده انگلیسی مقاله Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-α (Interlukin 1α) and TNF- α (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-α and TNF- α in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive RF, IL1-α, and TNF- α levels. Active with bone erosion patients had IL1-α and TNF- α serum levels higher than active without bone erosion patients; it was not significant in T-test but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-α, and TNF- α serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients.
کلیدواژه‌های انگلیسی مقاله cytokins
نویسندگان مقاله ar رستمیان | ar rostamian


ah ناجی | ah naji


f غریب دوست | f gharibdoost


a خلوت | a khalvat


l جعفری صراف k سعیدفر | l jafari saraf k saeedfar


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3323
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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