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Iranian Journal of Pediatric Hematology and Oncology، جلد ۷، شماره ۱، صفحات ۴۸-۵۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Methylenetetrahydrofolate Reductase Polymorphisms in Iranian Patients with Glanzmann’s Thrombasthenia
چکیده انگلیسی مقاله Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's thrombasthenia (GT) and the exact correlation between MTHFR polymorphisms and GT is not well established. This calls for further studies in populations with a large number of such patients. So, this study was performed to question whether coinheritance of MTHFR polymorphisms and GT can modulate the clinical phenotype of GT. Material and Methods: In the present case-control study which performed at Pathology and Stem Cell Research Center at Kerman University of Medical Sciences, 65 patients with GT and 100 normal voluntary blood donors as the control group were evaluated. The mean (SD) age of patients and the control group were 2.33±1.54 years (range 0-5 years) and 2.6±1.72, respectively. The detection of MTHFR C677T and A1298C polymorphisms was carried out using a Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) method. In accord with the Glanzmann's Thrombasthenia Italian Team (GLATIT) Protocol, the clinical severity of bleeding in patients with GT was determined. Two tests of descriptive statistics (i.e. frequencies) and Chi-square, using the SPSS version 19, were employed to analyze the data. Results: Based on results, there were no significant statistical differences in the prevalence of the MTHFR C677T polymorphism (P=0.703) or the MTHFR A1298C polymorphism (P=0.187) between patients and the control group. In addition, no association between the severity of bleeding and these polymorphisms was found (P=0.385). Conclusions: It was concluded that the thrombogenic mutations of MTHFR do not solely modulate the severity of clinical symptoms in patients with GT
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شیما کاظم زاده | shima kazemzadeh
department of laboratory hematology and blood banking, faculty of allied medicine, kerman university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

رضوان محمدی | rezvan mohammadi
pathology and stem cell research center, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

فاطمه شادکام فرخی | fatemeh shadkam farokhi
pathology and stem cell research center, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

علیرضا shafiian | alireza shafiian
school of veterinary medicine, shahid bahonar university of kerman, kerman, iran.

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

محمد فرانوش | mohammad faranoush
pediatric growth and development research center, endocrinology institute, iran university of medical science, tehran,


علیرضا فارسی نژاد | alireza farsinejad
pathology and stem cell research center, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

فریدون علا | fereydoun ala
professor of hematology, iranian comprehensive hemophilia care centre, tehran, iran.

سازمان های دیگر: Iranian Comprehensive Hemophilia Care Centre

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-112&slc_lang=fa&sid=en
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زبان مقاله منتشر شده en
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