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Iranian Journal of Pediatric Hematology and Oncology، جلد ۷، شماره ۱، صفحات ۶۳-۶۷
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عنوان انگلیسی Pleuropulmonary blastoma: report of 2 cases
چکیده انگلیسی مقاله Pleuropulmonary blastoma (PPB) is a rare, malignant intrathoracic tumor that occurs mostly in children before 5 years old. It consists about 15% of all primary pediatric pulmonary tumors and shows various mesenchymal components. Its presentations are nonspecific and common symptoms include fever, cough, chest pain, respiratory distress, and pulmonary infection. PPB should be considered in the differential diagnosis of solid and cystic lesions of thorax in children. Surgery is the main treatment of PPB that followed by chemotherapy. Radiotherapy has controversial effects on PPB. For recurrent tumors, bone marrow transplant is recommended. Two cases of this rare tumor is reported to increase the awareness about this entity and considering it in differential diagnosis of solid and cystic lesions of thorax in infants and children. The first case initially was treated with vincristine, actinomycin-D, and cyclophosphamide (VAC) regimen. Following relapse, it was scheduled with ifosfamide, vincristine, actinomycin-D and doxorubicin (IVADo) regimen and radiotherapy. Then, autologous stem cell rescue (ASCR) was recommended; but the patient was expired due to progressive disease before considering it. The second case was first treated with ifosfamide and doxorubicin alternate with ifosfamide and etoposide (IDo/ IE regimen). Following relapse, it was scheduled with ifosfamide, carboplatin and etoposide (ICE) chemotherapy regimen and he felt better.
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نویسندگان مقاله ناهید رییسی | nahid reisi
pediatric oncologist, associate professor of pediatric hematology and oncology, faculty of medicine, child growth and de


سعید یوسفیان | saeed yosefian
pediatric oncologist, assistant professor of pediatric hematology and oncology, child growth and development research ce


پردیس نعمت اللهی | pardis namatollahi
anatomical and clinical pathologist, assistant professor of pathology, isfahan university of medical sciences, isfahan,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-114&slc_lang=fa&sid=en
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زبان مقاله منتشر شده en
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