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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۳، صفحات ۳۷۶-۳۸۷
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چکیده فارسی مقاله
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عنوان انگلیسی Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine–induced hepatotoxicity and hemolytic anemia
چکیده انگلیسی مقاله Objective: Pistacia vera is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of Pistacia vera pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.Materials and Methods: PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.
کلیدواژه‌های انگلیسی مقاله Anemia, Hepatoprotective, Pistachio, Liver, Antioxidant
نویسندگان مقاله | Fatemeh Amin
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Najmeh Parvaz
Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Nahid Askari
Department of Biotechnology, Institute of Sciences and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran


| Morteza Khademalhosseini
Department of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Sakineh Kahanamani Falahati-pour
Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran


| Iman Fatemi
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran


| Fatemeh Khajehasani
Department of Radiology, Afzalipour Medicine School, Kerman University of Medical Sciences, Kerman, Iran


| Zahra Taghipour
Department of Anatomy, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Soudeh Khanamani Falahati-pour
Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_23925.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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