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Archives of Breast Cancer، جلد ۱۱، شماره ۲، صفحات ۱۲۶-۱۳۷
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عنوان انگلیسی Assessing MRI Sensitivity and Specificity for Detecting Occult Nipple-Areolar Complex Malignancy in Nipple-Sparing Mastectomy Candidates: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: Approximately 8% of breast cancers originate within the central ducts near the nipple-areolar complex(NAC), which revealed higher rates of occult involvement than previously thought. Precise preoperative imaging to assess NAC and subjacent tumor involvement has become critical to identify candidates for nipple-sparing mastectomy(NSM) while ensuring oncological safety. The aim of our study is to determine whether MRI could be used for the detection of subtle neoplastic infiltration. Method: Electronic databases including PubMed, Scopus, Web of Science, and EMBASE were systematically searched to identify all relevant studies on diagnostic performance of Magnetic Resonance Imaging(MRI) in malignant extension to the nipple published before 2024. The keywords include MRI, NAC, breast cancer, NSM. True Positive(TP), True Negative(TN), False Positive(FP), False Negative(FN) were extracted for analysis. Finally, 5 articles were selected for our meta-analysis. STATA version 15 was used to analysis data. Result: Our meta-analysis showed a pooled sensitivity of 89%(95% CI: 81%-94%)with low heterogeneity(I2 = 17.51%), and a pooled specificity of 89% (95% CI: 71%-96%), with significant heterogeneity(I2 = 95.87%). The pooled positive diagnostic likelihood ratio(pDLR) was 7.81(95% CI: 2.82-21.61, I2 = 92.66%), and the negative diagnostic likelihood ratio(nDLR) was 0.12(95% CI: 0.07-0.22, I2 = 11.94%). Conclusion: Diagnostic MRI characteristics such as NAC enhancement, non-mass enhancement(NME) type, mass size (greater than 20 mm), and tumor-to-nipple distance(TND) were assocaited with the presence of NAC involement. Because of high diagnostic accuracy, MRI imaging can be used as a helpful tool for NAC diagnosis.
کلیدواژه‌های انگلیسی مقاله sensitivity and specificity,Breast cancer (BC),Breast MRI,meta analysis,Nipple
نویسندگان مقاله | Nasrin Ahmadinejad
Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Amirreza Taherkhani
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Ramtin Hajibeygi
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Science, Tehran, Iran


| Mahmood Gorjizad
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Shirin Yaghoobpoor
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Reihaneh Mortazavi Ardestani
Department of Radiology, Tehran University of medical sciences, Tehran, Iran


| Mobina Fathi
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Science, Tehran, Iran";}


| Hamed Ghorani
Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mohammadreza Tahamtan
Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/906
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.32768/abc.2024112126-137
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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