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Archives of Breast Cancer، جلد ۱۱، شماره ۲، صفحات ۲۰۴-۲۰۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Pilot Study of Detecting RS920778 and RS1899663 Genetic Variants of HOTAIR in A Cohort of Sporadic Breast Cancer Patients in Sri Lanka: Genetic variants of HOTAIR
چکیده انگلیسی مقاله Background: Some functional single nucleotide polymorphisms (SNPs) on the HOTAIR gene are potent to elevate breast cancer risk where rs920778 and rs1899663 are associated with the expression and function of the HOTAIR gene, and these SNPs were detected in the current study. Methods: A cohort of nine sporadic cancer patients and five healthy controls were screened for selected HOTAIR variants using direct sequencing. Results: Among patients, seven were with TT genotype, and other 2 with CT genotype for rs920778 C>T while two healthy controls showed TT, another two were with CT, and the remaining with CC genotypes. Among the cohort, the rs1899663 variant was not found in any patients and healthy controls., Conclusion:  In the study, the T allele of rs920778 was prominent among the sporadic breast cancer in the studied cohort while only a wild allele (T) of rs1899663 was more prominent in the patients and healthy controls.
کلیدواژه‌های انگلیسی مقاله breast cancer, Sri Lanka, HOTAIR, gene, single nucleotide polymorphisms
نویسندگان مقاله | Sumadee De Silva
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo


| Asanka Sudeshini Hewag
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka


| Fathmath Anaan Shafeeu
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka


| Vahinipriya Manoharan
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka


| Kanishka De Silva
National Cancer Institute, Maharagama, Sri Lanka
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/877
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.32768/abc.2024112204-207
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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