این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Analytical and Bioanalytical Electrochemistry، جلد ۱۶، شماره ۴، صفحات ۳۱۵-۳۳۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Electrochemical Direct Detection of Glycated Hemoglobin (HbA1c) by Immobilized Glucose Oxidase on ZnO Nanostructures
چکیده انگلیسی مقاله Electrochemical method is used for glycated hemoglobin (HbA1c) detection using a new configuration of working electrodes coated by ZnO nanorods. HbA1c reflects the average plasma glucose over two months. In this work, HbA1c is directly detected electrochemically without any proteolytic digestion for the first time. ZnO nanorods modify the working electrode to increase the surface of sensing, leading to amplifying the electrochemical signal and providing a stable enzyme bed for GOx immobilization. The limit of detection (LOD) is 0.32 μg/μl which can be achieved in 40 seconds as the sensor's response time. The range of detection is 0.32 µg/µl (0.21% of HbA1c)-22.4 µg/µl (14.93% of HbA1c) that covers the standard diagnosis range. Due to embedded nanostructures, a small amount of about 2 μl GOx solution and 50 nl of blood is required for detection. The low response time makes this sensor suitable for fast tests such as diabetic population enumeration and screening. 
کلیدواژه‌های انگلیسی مقاله HbA1c,Electrochemical,Glucose oxidase,Zinc Oxide Nanostructures,Amperometry
نویسندگان مقاله Javad Koohsorkhi |
Advanced Micro and Nano Devices Lab., Faculty of New Sciences and Technologies, University of Tehran, North Kargar St. Tehran, Iran

Mehrshad Kafi |
Advanced Micro and Nano Devices Lab., Faculty of New Sciences and Technologies, University of Tehran, North Kargar St. Tehran, Iran

Sajjad Sanjari |
Advanced Micro and Nano Devices Lab., Faculty of New Sciences and Technologies, University of Tehran, North Kargar St. Tehran, Iran

نشانی اینترنتی https://www.abechem.com/article_712920_6b0ec083d9f6aa30733e3aeebd8d66fe.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات