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Veterinary Research Forum، جلد ۱۵، شماره ۵، صفحات ۲۵۷-۲۶۰
عنوان فارسی
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عنوان انگلیسی Epithelioid leiomyosarcoma arising from the ocular region in a dog
چکیده انگلیسی مقاله A 16-year-old male mixed-breed dog presented with a mass with hemorrhage at the right conjunctiva. Five months after the initial visit, the right eye protruded and had a firm and irregular mass measuring approximately 1.00 cm in diameter with conjunctival hemorrhage. Microscopically, the mass was comprised polygonal or round tumor cells with distinct cell borders arranged in a nested and diffuse pattern. The tumor cells had round-to-oval fine hyperchromatic nuclei containing distinct multiple nucleoli and abundant eosinophilic or pale cytoplasm. Multiple giant cells were frequently observed. The mitotic index was 12.60/high power field. Extensive necrosis, hemorrhage and part of the cord-like and papillary epithelioid cells were observed in the intra-tumor tissue. Immunohistochemically, the tumor cells were positive for vimentin and α-smooth muscle actin and negative for cytokeratin, desmin and PNL2. On the other hand, the cord-like and papillary epithelioid cells were positive for vimentin, S100 and neuron-specific enolase. The tumor was diagnosed as an epithelioid leiomyosarcoma. This case considered to have occurred in the ocular region, although the ocular structure was destroyed.
کلیدواژه‌های انگلیسی مقاله Epithelioid,Eye,Dog,Leiomyosarcoma,Smooth muscle actin
نویسندگان مقاله Tomokazu Nagashima |
Department of Veterinary Pathology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan

Chisato Kishi |
Department of Veterinary Pathology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan

Yukino Machida |
Department of Veterinary Pathology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan

Masaki Michishita |
Department of Veterinary Pathology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan

نشانی اینترنتی https://vrf.iranjournals.ir/article_711948_91e72d15577f4871acd8e976b2d04c28.pdf
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