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Acta Medica Iranica، جلد ۳۹، شماره ۲، صفحات ۷۶-۸۴
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عنوان انگلیسی Role of Oxygen-free radicals on the motility of rat ileum effects of Xanthine plus Xanthine Oxidase
چکیده انگلیسی مقاله The major objective of the present study was to characterize the effects of oxidants generated b xanthine (X) plus xanthine oxidase (XO) on isolated rat ileum motility. The effects of three concentrations of X/XO on the basal tone of the rat ileum preparation were studied for 20 minutes. Developed tensions were measured in mg/mg tissues and then expressed as percentage of baseline tension. Also the effects of 2X concentration of X/XO in the presence and absence of superoxide dismutase, catalase, mannital, histidine, and deferoxamine were evaluate. The results were expressed as mean ± SE. Xanthine puls xanthine exidase produced relaxation of ileum. Superoxide dismutase (a superoxide anion metabolizer) and catalase (a hydrogen peroxide scavenger) did not protect ileum from effects of X/XO suggesting that neither superoxide anion nor hydrogen peroxide involse in X/Xo- induced relaxation of ileum. The results of this study suggest that hydrogen peroxide formed extracelluarly by X/XO may enter the cells and interact with intracellular iron of form a highly reactive oxidant. Hydroxyl radical. The finding that two powerful hydroxyl radical scavengers, dimethylthiourea (DMTU) and mannitol offered protection against X/XO-induced relaxation of ileum suggest formation of hydroxyl radical withing the cells. Pretreatment with deferoxamin, a potents iron chelator, reduced the relaxation of ileum, indicating that hydroxyl radical plays an important role in mediating the X/XO –induced relaxation of ileum. In addition.The ability of exogenously administered histidine to reduce relaxation suggests that singlet oxyen is another oxygen derivative which is responsible for relaxation of ileum-induced by X/XO.
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نویسندگان مقاله نرگس ایزدی مود | izadi mood n


prasad k | prasad k


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/2409
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